中文名稱：細(xì)胞角蛋白18抗體（C端）
別名：Cell proliferation inducing gene 46 protein; Cell proliferation inducing protein 46; CK 18; CK18; CYK18; Cytokeratin 18; Cytokeratin endo B; Cytokeratin18; Keratin 18; Keratin D; Keratin type I cytoskeletal 18; Kerd; KRT18.  
英名稱：Cytokeratin 18 Monoclonal Antibody
產(chǎn)品類型：一抗
規(guī)格：30u/100ul/200ul
研究領(lǐng)域：腫瘤  細(xì)胞生物  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  
抗體來源：Mouse
克隆類型：Monoclonal
克 隆 號：3C3
交叉反應(yīng)：Human, Mouse, Rat,
產(chǎn)品應(yīng)用：WB=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量：48kDa
細(xì)胞定位：細(xì)胞漿 細(xì)胞膜
性    狀：Lyophilized or Liquid
濃    度：1mg/ml
免 疫 原：Recombinant human CK18:
亞    型：IgG
純化方法：affinity purified by Protein G
儲 存 液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件：for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

產(chǎn)品介紹：
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].

Function:
When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

Post-translational modifications:
Phosphorylation increases by IL-6.
Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-231 by either caspase-3, caspas-6 or caspase-7.
O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residue.