我公司致力于為客戶提供高純度、低成本的活性重組蛋白，包括重組人MANF(含His標(biāo)簽)在內(nèi)的各類受體、細(xì)胞因子、生長因子、轉(zhuǎn)錄因子、激素、酶、毒性蛋白、病毒抗原等。...

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產(chǎn)品名稱：重組人MANF(含His標(biāo)簽)
英文名稱：Recombinant Human Mesencephalic astrocyte-derived neurotrophic factor
產(chǎn)品貨號：JN0208
產(chǎn)品規(guī)格：10μg|50μg|500μg|1mg

本品由我們的哺乳動物表達系統(tǒng)制備，目的基因編碼的Leu25-Leu182在C端含有His標(biāo)簽。

MANF質(zhì)量控制：＞95%(還原性SDS-PAGE)。

MANF制劑：凍干品

MANF保存：
凍干蛋白可在-20℃長期保存，室溫也可穩(wěn)定保存3周。
復(fù)溶蛋白溶液可在4～7℃保存2～7天。
復(fù)溶后建議分裝凍存在-20℃，可保存3個月，應(yīng)避免反復(fù)凍融。

MANF復(fù)溶：
1、試劑開蓋前請先離心。
2、復(fù)溶濃度應(yīng)大于100 μg/ml.
3、凍干蛋白溶于ddH2O中
4、復(fù)溶后根據(jù)使用量分裝保存，避免反復(fù)凍融。

關(guān)于MANF：
Mesencephalic astrocyte-derived neurotrophic factor(MANF) is a secreted protein which belongs to the ARMET family. MANF selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. It modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. MANF enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. MANF inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. The N-terminal region of ARMET may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response. MANF reduces endoplasmic reticulum (ER) stress and has neurotrophic effects on dopaminergic neurons. Intracortical delivery of recombinant MANF protein protects tissue from ischemic brain injury. MANF has been described as a survival factor for dopaminergic neurons. MANF and a homologous protein, the conserved dopamine neurotrophic factor (CDNF), form a novel evolutionary conserved family of neurotrophic factors. MANF expression was widespread in the nervous system and non-neuronal tissues.

根據(jù)您的關(guān)注的重組人MANF(含His標(biāo)簽)，重組人MANF，重組MANF，rMANF，重組人Mesencephalic astrocyte-derived neurotrophic factor，重組Mesencephalic astrocyte-derived neurotrophic factor，rhMANF，Recombinant Human Mesencephalic astrocyte-derived neurotrophic factor，重組人含His標(biāo)簽，重組含His標(biāo)簽，您可能還對以下產(chǎn)品有需求：



名稱：重組人趨化因子CCL26(Eotaxin-3)
貨號：JN0305
規(guī)格：10μg|50μg|500μg|1mg
本品由我們的大腸桿菌表達系統(tǒng)制備，目的基因編碼的Thr24-Leu94表達純化而來。

CCL26/Eotaxin-3質(zhì)量控制：＞95%(還原性SDS-PAGE)。

CCL26/Eotaxin-3制劑：液體

CCL26/Eotaxin-3保存：
收到后請置于-20℃，可穩(wěn)定保存6個月，避免反復(fù)凍融。

關(guān)于CCL26/Eotaxin-3：
Chemokine Ligand 26 protein (CCL26) is a novel small cytokine belonging to the CC chemokine family which is involved in immunoregulatory and inflammatory processes. CCL26 is constitutively expressed in thymus, but only transiently expressed in phytohemagglutinin-stimulated peripheral blood mononuclear cells. It specifically binds and induces chemotaxis in T cells and elicits its effects by interacting with the chemokine receptor CCR4. CCL26, along with Eotaxin-1 and Eotaxin-2, selectively activates the CC chemokine receptor 3 (CCR3). The Eotaxin-3-CCR3 interaction may play an important role in allergic diseases such as atopic dermatitis and bronchial asthma. The full-length cDNA for CCL26 encodes a protein of 94 amino acids with a putative signal peptide of either 23 or 26 amino acid residues. Both the 71 and 68 amino acid residue variants of recombinant CCL26 demonstrate equal potency in inducing chemotaxis of a human CCR3-transfected cell line. Unlike most other CC chemokines, CCL26 maps to human chromosome 7q11.2, within 40 kilobases of the Eotaxin-2 loci. CCL26 and Eotaxin-2 are unique in that they are the only chemokines identified to date that map to chromosome 7.

關(guān)注重組人MANF(含His標(biāo)簽)，重組人MANF，重組MANF，rMANF，重組人Mesencephalic astrocyte-derived neurotrophic factor，重組Mesencephalic astrocyte-derived neurotrophic factor，rhMANF，Recombinant Human Mesencephalic astrocyte-derived neurotrophic factor，重組人含His標(biāo)簽，重組含His標(biāo)簽的同時，為您推薦更多您可能感興趣的產(chǎn)品：

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