我公司致力于為客戶提供高純度、低成本的活性重組蛋白，包括重組人Glypican 1在內(nèi)的各類受體、細(xì)胞因子、生長因子、轉(zhuǎn)錄因子、激素、酶、毒性蛋白、病毒抗原等。...

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產(chǎn)品名稱：重組人Glypican 1(GPC1)
英文名稱：Recombinant Human Glypican-1
產(chǎn)品貨號(hào)：JN1583
產(chǎn)品規(guī)格：10μg|50μg|500μg|1mg

本品由我們的哺乳動(dòng)物細(xì)胞表達(dá)系統(tǒng)制備而成，目的基因編碼的Asp24-Thr529在N端含有His標(biāo)簽。

Glypican 1質(zhì)量控制：＞95%(還原性SDS-PAGE)

Glypican 1制劑：凍干品

Glypican 1保存：
凍干蛋白置于-20℃以下可長期保存，室溫條件下可穩(wěn)定保存3周。
復(fù)溶蛋白溶液可在4～7℃保存2～7天，可分裝后置于-20℃保存三個(gè)月。

Glypican 1復(fù)溶：
打開試劑管前請(qǐng)先離心。
復(fù)溶濃度推薦大于100 μg/ml。
凍干蛋白請(qǐng)溶于ddH2O。
復(fù)溶后，請(qǐng)根據(jù)用量分裝凍存，避免反復(fù)凍融。

關(guān)于Glypican 1：
The Glypicans are a small multigene family of GPI-linked proteoglycans that play a key role in growth factor signaling. Human Glypican 1 (GPC1) is synthesized as a 558 amino acid (aa) preproprecursor that contains a 23 aa signal sequence, a 507 aa mature segment, and a 28 aa C-terminal prosegment. There are two potential N-linked and four potential O-linked sites for glycosylation or glycanation. There are potentially two heparan sulfate (HS) modifications on GPC1 that could contribute to a native molecular weight of approximately 200 kDa. Mature human GPC1 shares 91% aa identity with mature mouse GPC1. Cells known to express GPC1 include neurons, smooth and skeletal muscle cells, keratinocytes, osteoblasts, Schwann cells, immature dendritic cells, and tumor, plus tumorassociated vascular endothelial cells. The function of GPC1 is complex and varied. As a proteoglycan, it appears to make use of its HS adduct to impact select growth factor activity. This is accomplished by having juxtramembrane HS attachment sites, and a flexible, GPI-linkage.

根據(jù)您的關(guān)注的重組人Glypican 1(GPC1)，重組人Glypican 1，rhGlypican-1，重組GPC1，重組人Glypican-1，rGPC1，Recombinant Human Glypican-1，rGlypican-1，重組Glypican-1，rhGPC1，重組人GPC1，重組Glypican 1，您可能還對(duì)以下產(chǎn)品有需求：



名稱：重組人白介素IL-25(白細(xì)胞介素25)
貨號(hào)：JN0355
規(guī)格：10μg|50μg|500μg|1mg
本品由我們的大腸桿菌表達(dá)系統(tǒng)制備，表達(dá)蛋白包含序列(Tyr33-Gly177)。

IL-25質(zhì)量控制：＞95%(SEC-HPLC，還原性SDS-PAGE)

IL-25制劑：凍干品

IL-25保存：
凍干蛋白可在-20℃長期保存，室溫也可穩(wěn)定保存3周。
復(fù)溶蛋白溶液可在4～7℃保存2～7天。
復(fù)溶后建議分裝凍存在-20℃，可保存3個(gè)月，應(yīng)避免反復(fù)凍融。

IL-25復(fù)溶：
1、試劑開蓋前請(qǐng)先離心。
2、復(fù)溶濃度應(yīng)大于100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
4、復(fù)溶后根據(jù)使用量分裝保存，避免反復(fù)凍融。

關(guān)于IL-25：
Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins, which is comprised of six members (IL-17, IL-17B through IL-17F). These proteins are secreted and are structurally related by sharing a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Human interleukin-17E (IL17E), also referred to as Interleukin-25 (IL25), is a distinct member of the IL17 cytokine family comprised of at least six members sharing a conserved cysteine-knot structure but divergent at the N-terminus. IL25 is a glycoprotein secreted as dimers by innate effector eosinophils and basophils, and present at very low levels in various peripheral tissues. IL25, together with IL17B, are ligands for the cytokine receptor IL17BR, and the cross-linking induces NF-κB activation and production of the proinflammatory chemokine IL-8, as well as ERK, JNK, and p38 activation. Overexpression of IL25 gene in transgenic mice suggested that this cytokine can regulate hematopoietic and immune functions, and additionally is identified as a proinflammatory cytokine favoring Th2-type immune responses possibly by enhancing the maintenance and functions of adaptive Th2 memory cells. Human IL-17E cDNA encodes a 177 amino acid residues precursor protein with a putative 32 amino acid signal peptide. A second isoform of human IL-17E encoding a 161 amino acid precursor protein also exists.

關(guān)注重組人Glypican 1(GPC1)，重組人Glypican 1，rhGlypican-1，重組GPC1，重組人Glypican-1，rGPC1，Recombinant Human Glypican-1，rGlypican-1，重組Glypican-1，rhGPC1，重組人GPC1，重組Glypican 1的同時(shí)，為您推薦更多您可能感興趣的產(chǎn)品：


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